Impairments of speech fluency in Lewy body spectrum disorder  

Oleh:

Ash, Sharon ; McMillan, Corey ; Gross, Rachel G. ; Cook, Philip ; Gunawardena, Delani ; Morgan, Brianna ; Boller, Ashley ; Siderowf, Andrew ; Grossman, Murray

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Brain and Language (Full Text) vol. 120 no. 3 (2012), page 290-302.
Topik: Parkinson’s disease; Speech; Language; Fluency; Dementia with Lewy bodies
Fulltext: 120_03_Ash.pdf (488.36KB)

Isi artikel

Few studies have examined connected speech in demented and non-demented patients with Parkinson’s disease (PD). We assessed the speech production of 35 patients with Lewy body spectrum disorder (LBSD), including non-demented PD patients, patients with PD dementia (PDD), and patients with dementia with Lewy bodies (DLB), in a semi-structured narrative speech sample in order to characterize impairments of speech fluency and to determine the factors contributing to reduced speech fluency in these patients. Both demented and non-demented PD patients exhibited reduced speech fluency, characterized by reduced overall speech rate and long pauses between sentences. Reduced speech rate in LBSD correlated with measures of between-utterance pauses, executive functioning, and grammatical comprehension. Regression analyses related non-fluent speech, grammatical difficulty, and executive difficulty to atrophy in frontal brain regions. These findings indicate that multiple factors contribute to slowed speech in LBSD, and this is mediated in part by disease in frontal brain regions.

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