A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia  

Oleh:

Speedy, Helen E ; Di Bernardo, Maria Chiara ; Sava, Georgina P. ; Holroyd, Amy

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Genetics vol. 46 no. 01 (Jan. 2014), page 56-60.
Topik: Lymphocytic Leukemia; Human genome

Ketersediaan

Perpustakaan FK Nomor Panggil: N12.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 × 10-9), 4q26 (rs6858698, P = 3.07 × 10-9), 6q25.2 (IPCEF1, rs2236256, P = 1.50 × 10-10) and 7q31.33 (POT1, rs17246404, P = 3.40 × 10-8). Additionally, we identified a promising association at 5p15.33 (CLPTM1L, rs31490, P = 1.72 × 10-7) and validated recently reported putative associations at 5p15.33 (TERT, rs10069690, P = 1.12 × 10-10) and 8q22.3 (rs2511714, P = 2.90 × 10-9). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CLL.

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