Self-Assembly and Hydrogelation of Peptide Amphiphiles  

Oleh:

Irwansyah ; Sihombing, Riwandi ; Suwarso, Wahyudi Priyono

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Makara Seri Sains vol. 16 no. 01 (Apr. 2012), page 51-57.
Topik: low molecular weight gelator; MALDI; peptide amphiphile; self-assembly; solid phase peptide synthesis
Fulltext: 1281-2637-3-PB_Ros.pdf (1.76MB)

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Perpustakaan Pusat (Semanggi) Nomor Panggil: MM65 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Seven peptide amphiphiles were successfully synthesized using solid phase peptide synthesis method. Peptide amphiphiles were characterized using Matrix-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometer (MALDI-TOF MS). Atomic force microscopy (AFM) study showed that peptide amphiphiles having glycine, valine, or proline as linker, self-assembled into 100-200 nm nanofibers structure. According to our research, both peptide amphiphile with positive and negative charges bear similar self-assembly properties. Peptide amphiphile also showed its capability as low molecular weight gelator (LMWG). Peptide amphiphiles bearing C-16 and C-12 as alkyl showed better hydrogelation properties than C-8 alkyl. Five out of seven peptide amphiphiles have minimum gelation concentration (MGC) lower than 1% (w/v).

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