Correlation Between T2* Cardiovascular Magnetic Resonance with Left Ventricular Function and Mass in Adolescent and Adult Major Thalassemia Patients with Iron Overload  

Oleh:

Djer, Mulyadi M. ; Anggriawan, Shirley L. ; Gatot, Djajadiman ; Amalia, Pustika ; Sastroasmoro, Sudigdo ; Widjaja, Patricia

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Acta Medica Indonesiana vol. 45 no. 04 (Oct. 2013), page 295-301.
Topik: T2* cardiovascular magnetic resonance; diastolic dysfunction; iron overload; thalassemia major; disfungsi diastolik; kelebihan besi; talasemia mayor
Fulltext: 07. Djer - Correlation Between T2.pdf (1.86MB)

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Perpustakaan FK Nomor Panggil: A02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Aim: to assess for a correlation between T2*CMR with LV function and mass in thalassemic patients with iron overload. Methods: a cross-sectional study on thalassemic patients was conducted between July and September 2010 at Cipto Mangunkusumo and Premier Hospitals, Jakarta, Indonesia. Clinical examinations, review of medical charts, electrocardiography, echocardiography, and T2*CMR were performed. Cardiac siderosis was measured by T2*CMR conduction time. Left ventricle diastolic and systolic functions, as well as LV mass index were measured using echocardiography. Correlations between T2*CMR and echocardiography findings, as well as serum ferritin were determined using Pearson’s and Spearman’s tests. Results: thirty patients aged 13-41 years were enrolled, of whom two-thirds had ß-thalassemia major and one-third had HbE/ß-thalassemia. Diastolic dysfunction was identified in 8 patients, whereas systolic function was normal in all patients. Increased LV mass index was found in 3 patients. T2*CMR conduction times ranged from 8.98 to 55.04 ms and a value below 20 ms was demonstrated in 14 patients. There was a statistically significant moderate positive correlation of T2*CMR conduction time with E/A ratio (r = 0.471, P = 0.009), but no correlation was found with LV mass index (r=0.097, P=0.608). A moderate negative correlation was found between T2*CMR and serum ferritin (r = -0.514, P = 0.004), while a moderate negative correlation was found between serum ferritin and E/A ratio (r = -0.425, P = 0.019). Conclusion: T2*CMR myocardial conduction time has a moderate positive correlation with diastolic function, moderate negative correlation with serum ferritin, but not with LV mass index and systolic function.

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