Are urinary bisphenol A levels in men related to semen quality and embryo development after medically assisted reproduction?  

Oleh:

Knez, Jure ; Kranvogl, Roman ; Breznik, Barbara Pregl ; Voncina, Ernest ; Vlaisavljevic, Veljko

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 101 no. 01 (Jan. 2014), page 215-221.
Topik: Bisphenol A; embryo development; semen quality; male reproductive health

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2014.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To evaluate whether urinary bisphenol A (BPA) levels in men adversely influence semen quality and embryo development after medically assisted reproduction. Design Prospective, cohort study. Setting University-based tertiary care center. Patient(s) A total of 149 couples undergoing their first or second IVF or intracytoplasmic sperm injection (ICSI) procedure. Intervention(s) None. Main Outcome Measure(s) Semen quality and embryo development parameters until the blastocyst stage after the IVF or ICSI procedure. Result(s) Bisphenol A was detected in 98% (n = 146) of the samples with 0.1 ng/mL limit of detection. The geometric mean BPA concentration was 1.55 ng/mL. After the adjustment for potential confounders using linear regression models, an increase of natural logarithm transformed urinary BPA concentration was associated with lower natural logarithm transformed sperm count (ß = -0.241, 95% confidence interval [CI] -0.470 to -0.012), natural logarithm transformed sperm concentration (ß = -0.219, 95% CI -0.436 to -0.003), and sperm vitality (ß = -2.660, 95% CI -4.991 to -0.329). The embryo development parameters from oocyte fertilization to the blastocyst formation stage were not affected by BPA exposure. Conclusion(s) Urinary BPA concentrations in male partners of subfertile couples may influence semen quality parameters, but do not affect embryo development up to the blastocyst stage after medically assisted reproduction.

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