Normal live births after intracytoplasmic sperm injection in a man with the rare condition of Eagle-Barrett syndrome (prune-belly syndrome)  

Oleh:

Fleming, Steven D. ; Varughese, Elizabeth ; Hua, Vi-Khiem ; Robertson, Amanda ; Dalzell, Fiona

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 100 no. 06 (Dec. 2013), page 1532-1535.
Topik: Eagle-Barrett syndrome (prune belly); intracytoplasmic sperm injection (ICSI); orchidopexy

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2013.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To report the first live births of male infants resulting from intracytoplasmic sperm injection (ICSI) using spermatozoa from a man with Eagle-Barrett syndrome (EBS). Design Case report. Setting Assisted conception unit within a private hospital. Patient(s) An infertile couple. Interventions An infertile couple received repeated treatment with ICSI. Main Outcome Measure(s) Clinical pregnancy and a normal live birth. Result(s) In 2008, after microinjection of ten oocytes, the transfer of a single expanded blastocyst led to the premature birth of a morphologically normal male infant at 18 weeks' gestation. This outcome followed preterm rupture of membranes and possible cervical incompetence. In 2009, after microinjection of six oocytes, transfer of a single 5-cell embryo led to a singleton pregnancy, with emergency cervical cerclage being performed at 21 weeks. A healthy male infant was born at 30 weeks, with no evidence of EBS, by lower-segment cesarean section for breech presentation and premature labor. In 2012, after elective laparoscopic placement of cervical suture, microinjection of ten oocytes and transfer of a single 4-cell embryo led to a singleton pregnancy with a healthy male infant, with no evidence of EBS, being born by cesarean section at 38 weeks. Conclusion(s) This report suggests that EBS is not transmitted to male offspring via ICSI.

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