Age and Homocystein were Risk Factor for Peripheral Arterial Disease in Elderly with Type 2 Diabetes Mellitus  

Oleh:

Kuswardhani, RA. Tuty ; Suastika, Ketut

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Acta Medica Indonesiana vol. 42 no. 2 (Apr. 2010), page 94-99.
Topik: elderly; type 2 diabetes mellitus; homocystein; ADMA; peripheral arterial disease.
Fulltext: age and homocystein.pdf (64.85KB)

Isi artikel

Aim: to find out the magnitude of risk of some traditional and non-traditional risk factors for PAD event in the elderly with Type 2 diabetes mellitus (T2DM) patients. Methods: a case-control study involved 40 subjects of each arms (case and control group) at Geriatric Outpatient Clinic Sanglah Hospital, Denpasar, Bali, Indonesia was conducted. Results: the study showed that compared to patients wihout PAD, patients with PAD had higher age (70.7 vs. 65.0 years; p<0.001), lower waist circumference (82.7 vs. 91.3 cm; p=0.019), lower triglyceride levels (127.8 vs. 173.9 mg/dl; p = 0.016), and higher homocystein levels (13.4 vs. 11.5 mmol/L, p = 0.023); while other variables revealed no any significantly difference between two groups. Although no any significant difference, subjects with PAD tend to do exercise less prevalent, consumed anti-hyperlipidemic and antithrombotic more frequent compared to subjects without PAD. High age (70-80 years) has risk 7.4 time than those lower age (60-69 years), and high homocystein level (e”11 mmol/ L) has risk 2.5 time than those with lower level to develop PAD. By multivariate analysis (logistic regression), only age has a role in PAD event, while homocystein tend to be risk factor for PAD event. Conclusions: some traditional risk factors and non-traditional risk factors unproved as risk factors for PAD event in the elderly with type 2 diabetes. Older age and homocystein level were risk factors for PAD event in the elderly with type 2 diabetes subjects.

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