Antimüllerian hormone as predictor of reproductive outcome in subfertile women with elevated basal follicle-stimulating hormone levels: a follow-up study  

Oleh:

Yarde, Felicia ; Voorhuis, Marlies ; Dolleman, Madeleine ; Knauff, Erik A.H. ; Eijkemans, Marinus J.C.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 100 no. 03 (Sep. 2013), page 831-838.
Topik: Subfertility; elevated basal FSH; antimüllerian hormone; prediction; live birth

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2013.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To investigate the role of serum antimüllerian hormone (AMH) as a predictor of live birth and reproductive stage in subfertile women with elevated basal FSH levels. Design A prospective observational cohort study conducted between February 2005 and June 2009. Setting Tertiary fertility center. Patient(s) Subfertile women with [1] a regular menstrual cycle (mean cycle length 25–35 days); [2] basal FSH concentrations =12.3 IU/L; and [3] younger than 40 years (n = 96). Intervention(s) None. Main Outcome Measure(s) Live birth and reproductive stage according to the Stages of Reproductive Aging Workshop. Result(s) A cumulative live birth rate of 63.5% was observed during a median follow-up of 3.3 years (n = 85). The AMH level was significantly associated with live birth. There was evidence of a nonlinear prediction pattern, with an increase in chances of live birth until an AMH level of 1 µg/L. Other ovarian reserve tests and chronological age appeared of limited value in predicting live birth. In addition, AMH was significantly associated with the timing of reproductive stages (n = 68) (i.e., the occurrence of menopausal transition or menopause during follow-up). Conclusion(s) The present findings suggest applicability of AMH determination as a marker for actual fertility in subfertile women with elevated basal FSH levels.

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