Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial  

Oleh:

Scott, Richard T., (Jr.) ; Upham, Kathleen M. ; Forman, Eric J. ; Hong, Kathleen H. ; Scott, Katherine L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 100 no. 03 (Sep. 2013), page 697-703.
Topik: IVF; preimplantation genetic screening; embryonic aneuploidy; comprehensive chromosomal screening; blastocyst

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2013.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To determine whether blastocyst biopsy and rapid quantitative real-time polymerase chain reaction (qPCR)–based comprehensive chromosome screening (CCS) improves in vitro fertilization (IVF) implantation and delivery rates. Design Randomized controlled trial. Setting Academic reproductive medicine center. Patient(s) Infertile couples in whom the female partner (or oocyte donor) is between the ages of 21 and 42 years who are attempting conception through IVF. Intervention(s) Embryonic aneuploidy screening. Main Outcome Measure(s) Sustained implantation and delivery rates. Result(s) We transferred 134 blastocysts to 72 patients in the study (CCS) group and 163 blastocysts to 83 patients in the routine care (control) group. Sustained implantation rates (probability that an embryo will implant and progress to delivery) were statistically significantly higher in the CCS group (89 of 134; 66.4%) compared with those from the control group (78 of 163; 47.9%). Delivery rates per cycle were also statistically significantly higher in the CCS group. Sixty one of 72 treatment cycles using CCS led to delivery (84.7%), and 56 of 83 (67.5%) control cycles ultimately delivered. Outcomes were excellent in both groups, but use of CCS clearly improved patient outcomes. Conclusion(s) Blastocyst biopsy with rapid qPCR-based comprehensive chromosomal screening results in statistically significantly improved IVF outcomes, as evidenced by meaningful increases in sustained implantation and delivery rates. Clinical Trial Registration Number NCT01219283. Earn online CME credit related to this document at www.asrm.org/elearn

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