Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk  

Oleh:

Broderick, Peter ; Chubb, Daniel ; Johnson, David C

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Genetics vol. 44 no. 01 (Jan. 2012), page 58–61.

Ketersediaan

Perpustakaan FK Nomor Panggil: N12.K.2012.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10-9) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10-15). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 × 10-7). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.

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