Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry  

Oleh:

Hunt, Karen A ; Smyth, Deborah J. ; Balschun, Tobias

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Genetics vol. 44 no. 01 (Jan. 2012), page 3–5.

Ketersediaan

Perpustakaan FK Nomor Panggil: N12.K.2012.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Recently, rare loss-of-function genetic variants in the SIAE gene, which encodes sialic acid acetylesterase, were reported to predispose to multiple autoimmune diseases1. In a pooled analysis of samples from ten autoimmune diseases, Surolia et al. identified 12 distinct nonsynonymous SIAE risk variant genotypes present in 24 of 923...

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