Child dopamine active transporter 1 genotype and parenting: Evidence for evocative gene-environment correlations  

Oleh:

Kim, Jiyon ; Hanna, Brigitte ; Hayden, Elizabeth P. ; Klein, Daniel N. ; Laptook, Rebecca S. ; Sheikh, Haroon I. ; Singh, Shiva M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 25 no. 1 (Feb. 2013), page 163-173.
Topik: Dopamine Active Transporter 1 (DAT1) Gene; Psychopathology Risk; Negative Emotionality; Negative Parenting Practices

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21.24 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The dopamine active transporter 1 (DAT1) gene is implicated in psychopathology risk. Although the processes by which this gene exerts its effects on risk are poorly understood, a small body of research suggests that the DAT1 gene influences early emerging negative emotionality, a marker of children's psychopathology risk. As child negative emotionality evokes negative parenting practices, the DAT1 gene may also play a role in gene–environment correlations. To test this model, children (N = 365) were genotyped for the DAT1 gene and participated in standardized parent–child interaction tasks with their primary caregiver. The DAT1 gene 9-repeat variant was associated with child negative affect expressed toward the parent during parent–child interactions, and parents of children with a 9-repeat allele exhibited more hostility and lower guidance/engagement than parents of children without a 9-repeat allele. These gene–environment associations were partially mediated by child negative affect toward the parent. The findings implicate a specific polymorphism in eliciting negative parenting, suggesting that evocative associations play a role in elevating children's risk for emotional trajectories toward psychopathology risk.

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