Anda belum login :: 24 Jul 2025 15:40 WIB
Home
|
Logon
Hidden
»
Administration
»
Collection Detail
Detail
Generation of functional insulin-producing cells in the gut by Foxo1 ablation
Oleh:
Talchai, Chutima
;
Shouhong, Xuan
;
Kitamura, Tadahiro
Jenis:
Article from Journal - ilmiah internasional
Dalam koleksi:
Nature Genetics vol. 44 no. 04 (Apr. 2012)
,
page 406–412.
Ketersediaan
Perpustakaan FK
Nomor Panggil:
N12.K.2012.01
Non-tandon:
1 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
Restoration of regulated insulin secretion is the ultimate goal of therapy for type 1 diabetes. Here, we show that, unexpectedly, somatic ablation of Foxo1 in Neurog3+ enteroendocrine progenitor cells gives rise to gut insulin-positive (Ins+) cells that express markers of mature ß cells and secrete bioactive insulin as well as C-peptide in response to glucose and sulfonylureas. Lineage tracing experiments showed that gut Ins+ cells arise cell autonomously from Foxo1-deficient cells. Inducible Foxo1 ablation in adult mice also resulted in the generation of gut Ins+ cells. Following ablation by the ß-cell toxin streptozotocin, gut Ins+ cells regenerate and produce insulin, reversing hyperglycemia in mice. The data indicate that Neurog3+ enteroendocrine progenitors require active Foxo1 to prevent differentiation into Ins+ cells. Foxo1 ablation in gut epithelium may provide an approach to restore insulin production in type 1 diabetes.
Opini Anda
Klik untuk menuliskan opini Anda tentang koleksi ini!
Kembali
Process time: 0 second(s)