Ability of Curcuminoid Compared to Diclofenac Sodium in Reducing the Secretion of Cycloxygenase-2 Enzyme by Synovial Fluid’s Monocytes of Patients with Osteoarthritis  

Oleh:

Kertia, Nyoman ; Asdie, Ahmad H. ; Rochmah, Wasilah ; Marsetyawan

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Acta Medica Indonesiana vol. 44 no. 2 (Apr. 2012), page 105-113.
Topik: Curcuminoid; diclofenac sodium; cyclooxygenase-2; osteoarthritis
Fulltext: Ability of Curcuminoid Compared to Diclofenac Sodium.pdf (1.17MB)

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Perpustakaan FK Nomor Panggil: A02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Aim: to assess the ability of curcuminoid from Curcuma domestica Val in reducing the cycloxygenase-2 secretion by synovial fluid’s monocytes compared to diclofenac sodium in patients with osteoarthritis. Methods: this was a prospective randomized open end blinded evaluation (PROBE) study. The subjects were patients with knee osteoarthritis who were divided randomly into two groups, the first group received 30 mg 3 times daily of curcuminoid and the second group received 25 mg 3 times daily of diclofenac sodium. The joints aspiration was done and the secretion of cycloxygenase-2 enzyme by synovial fluid’s monocytes was evaluated by scoring method before and after 4 weeks of treatments. Results: a total of 80 patients with knee osteoarthritis were enrolled. In curcuminoid group the average scores were 1.84±0.37 and 1.15±0.28 respectively (p<0.001). In diclofenac group the average scores were 1.79±0.38 and 1.12±0.27 respectively (p<0.001). In curcuminoid group the decreasing score of cycloxygenase-2 secretion was 0.70±0.51 while in diclofenac group was 0.67±0.45. There was no significant difference in decreasing the score of cycloxygenase enzyme secretion between both treatment groups (p=0.89). Conclusion: the ability of curcuminoid from Curcuma domestica Val. rhizome extract was not significantly different compared to diclofenac sodium in suppressing the secretion of cycloxygenase-2 enzyme by synovial fluid’s monocytes.

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