Prevalence of Hepatic Steatosis in Chronic Hepatitis B Patients and Its Association with Disease severity  

Oleh:

Lesmana, Laurentius A. ; Lesmana, C. Rinaldi A. ; Pakasi, Levina S. ; Krisnuhoni, Ening

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Acta Medica Indonesiana vol. 44 no. 01 (Jan. 2012), page 35-39.
Topik: Liver steatosis; chronic hepatitis B; liver fibrosis.
Fulltext: Prevalence of Hepatic Steatosis.pdf (999.06KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: A02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Aim: to know the prevalence of liver steatosis in chronic hepatitis B (CHB) patients and evaluate whether its presence was associated with a more progressive disease. Methods: a cross-sectional study was conducted in Cipto Mangunkusumo and Medistra Hospitals, Jakarta on CHB patients between 2007 and 2009. Data on patients’ demography, anthropometry, liver function test and hepatitis B serology were collected. Hepatic steatosis was assessed by liver biopsy and graded as mild (<33%), moderate (33-66%) or severe (>66%). Fibrosis stage and necroinflammatory activity were assessed according to the METAVIR system. Results: one-hundred and seventy four patients were enrolled; 99 (56.9%) among them were men. Patients’ mean age was 39.9+10.69 years. About 56% of cases were HBeAg negative. The prevalence of liver steatosis was 29.9%. Patients with liver steatosis had significantly higher body mass index (25.1+3.3 vs. 22.7+3.33 kg/m2, p<0.001) and waist circumference (88.3 vs. 79.0 cm; p<0.001). No association between liver steatosis and HBeAg status (p=0.736). There were no differences of log HBV-DNA levels (5.72+1.993 vs. 6.07+2.077; p=0.675) and liver stiffness (8.3+6.28 vs. 9.5+10.18 kPa) between patients with and without liver steatosis. The presence of significant fibrosis (61.5% vs. 69.7%; p=0.295) and necroinflammation (63.5% vs. 65.6%; p=0.789) was not differed between patients with and without liver steatosis. Conclusion: liver steatosis was found in 30% of chronic hepatitis B patients. Its presence was mostly associated with central obesity. Unlike chronic hepatitis C, liver steatosis in chronic hepatitis B was not related to a more progressive disease.

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