A Meta-analysis on Treatment Effects of Thiazolidinediones for Type 2 Diabetes Mellitus in Asian Populations  

Oleh:

Louisa, Melva ; Takeuchi, Madoka ; Takeuchi, Masahiro ; Nafrialdi ; Setiabudy, Rianto

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Acta Medica Indonesiana vol. 43 no. 1 (Jan. 2011), page 39-52.
Topik: Thiazolidinediones; pioglitazone; rosiglitazone; type 2 diabetes mellitus; Asian population.
Fulltext: A Meta-analysis on Treatment Effects.pdf (2.72MB)

Ketersediaan

Perpustakaan FK Nomor Panggil: A02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Aim: to assess the effects of thiazolidinediones (pioglitazone and rosiglitazone) in the treatment of T2DM in Asian population. Methods: randomized controlled trials of T2DM patients in Asian population that compared pioglitazone or rosiglitazone with other treatments for more than 3 months and reported HbA1c data were included. Analyses for all outcomes were calculated using random effect model. Results: the analyses included 37 studies in approximately 3,000 patients. Thiazolidinediones had beneficial effect on HbA1c (glycosylated hemoglobin/ hemoglobin A1c) compared with control (weighted mean difference (WMD) -0.12%; 95% CI [confidence interval], -0.54 to -0.19% for pioglitazone and -0.47%; 95% CI, -0.89 to -0.40% for rosiglitazone). Overall, TZDs showed significant benefit on glycemic outcomes measured by HbA1c as main surrogate outcome compared with previous glycemic control but not with other anti-diabetics. Conclusion: thiazolidinediones treatment resulted in favorable effects on glycemic control in Asian patients with T2DM. Long-term efficacy and safety data of TZD could not yet be confirmed due to the lack of randomized studies with patient-oriented outcomes.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali