Altered insulin-induced relaxation of aortic rings in a dihydrotestosterone-induced rodent model of polycystic ovary syndrome  

Oleh:

Masszi, Gabriella ; Buday, Anna ; Novak, Agnes ; Horvath, Eszter Maria ; Aritonang, John V.L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 99 no. 02 (Feb. 2013), page 573-578.
Topik: Rat; vascular insulin resistance; dihydrotestosterone; vitamin D; PCOS

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2013.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To clarify the effects of dihydrotestosterone (DHT)–induced polycystic ovary syndrome (PCOS) on the insulin-dependent vasodilatation of the thoracic aorta and the role of vitamin D in a rat model. Design Controlled experimental animal study. Setting Laboratory. Animal(s) Thirty adolescent female Wistar rats. Intervention(s) The PCOS model was induced by 10 weeks of DHT treatment (83 µg/d). One-half of the DHT-treated animals also received vitamin D (120 ng/kg/wk). Main Outcome Measure(s) The aortic rings of the control, DHT, and DHT plus vitamin D–treated animals were isolated. The insulin-dependent vasodilation of the isolated aortic rings was compared in Krebs-Ringer solution and under blockade of nitric oxide (NO) synthase or cyclooxygenase. Result(s) The insulin-dependent vasorelaxation decreased in both DHT-treated groups independently from the vitamin D treatment; NO-dependent and -independent relaxations were both impaired. In response to prostanoid, vasoconstriction was increased after DHT treatment. The NO-independent relaxation was partially improved by vitamin D treatment, which was neutralized by increased prostanoid-dependent vasoconstriction. Conclusion(s) Previously, we found that vitamin D treatment prevented systemic insulin resistance; however, in this study, we did not detect any influence on the vascular insulin resistance of the aorta that was induced by DHT treatment. Consequently, controlling insulin resistance with vitamin D alone did not resolve the aortic endothelial dysfunction caused by the hyperandrogenic state.

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