Idiopathic liver function test abnormality in pregnancy is associated with assisted reproduction techniques  

Oleh:

Kopylov, Uri ; Avidan, Benjamin ; Papageorgiou, Neofytos P. ; Katz, Lior H. ; Aritonang, John V.L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 99 no. 02 (Feb. 2013), page 377-381.
Topik: Assisted reproduction techniques; liver test abnormality; intrahepatic cholestatis of pregnancy; HELLP; preeclampsia

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2013.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To examine the prevalence, etiology, risk factors, and outcomes of liver abnormality in pregnancy, in a tertiary medical center, and to study the potential impact of artificial reproduction techniques (ART) on the incidence and the outcome of pregnancy-related liver abnormality. Design A retrospective case-control study using an electronic database and patients’ files. Setting Tertiary referral center. Patient(s) Women in the third trimester of pregnancy who were hospitalized for delivery. Intervention(s) None. Main Outcome Measure(s) Development of significant elevation of alanine aminotransferase (ALT =100 IU/L). Secondary outcomes included development of maternal and fetal complications. Result(s) The upper limit of normal of ALT was =1.5 times and it occurred in 440 (1.6%) pregnancies; of those, 228 (0.8%) had ALT =100 IU/L. The etiology of significant liver test abnormality was idiopathic in 47% of patients. Compared with spontaneous pregnancies (295/23,793), ART was significantly associated with liver test abnormality (145/4, 520). The presence of ALT =100 IU/L in the third trimester was associated with higher rates of cesarean sections, prematurity, low birthweight, and fetal complications. Conclusion(s) A definite etiology was not determined in about half of pregnancy-associated liver test abnormality. The ART was significantly associated with liver test elevation. Significant liver test abnormality in the third trimester may have an impact on maternal and fetal/neonatal outcomes.

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