Perbandingan Efektifitas Kloramfenikol dan Gentamisin pada Dakriosistitis Bayi: Effectiveness of Gentamicin and Chloramfenicol for Infant Dacryicistitis  

Oleh:

Indrajati, Christina ; Handojo, Norma D. ; Wiranto

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Sains Medika (Jurnal Kedokteran dan Kesehatan) vol. 03 no. 02 (Jul. 2011), page 105-111.
Topik: Dacryocistitis; Pattern of Bacteria; Sensitivity Test; Chloramfenicol; Gentamicin
Fulltext: Efektifitas Kloramfenikol.pdf (166.57KB)

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Perpustakaan FK Nomor Panggil: S11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Background: Dacryocistitis is an infection of lacrimal system due to blockage of Hasner valve by a membranecommonly found in infant. The management of dacryocistitis includes nasolacrimal massage and topicalbroad spectrum antibiotics since chloramfenicol and gentamicin are widely used in regional hospital primaryhealth care in Indonesia, the effectiveness of the two antibiotics require an assessment. This study wasconducted to compare the clinical and bacteriological effectiveness of gentamicin and chloramfenicol forinfant dacryicistitis to describe the etiologic bacterial and its sensitivity pattern.Design and Method: A randomized control trial study included 46 patients divided equally into two groups.Group K received one drop chloramfenicol six times per day and group G receive one drop gentamicin sixtimes per day. Both of groups received therapy for 14 days. Clinical evaluation was done on week I and weekII. Microbiological evaluation was performed before treatment and at the end of week two. Criteria forclinical recovery were the disappearance of the sign and symptoms of dacryocistitis, while microbiologicrecovery ruled out when there is no bacteria find out on secret and lacrimal system. Antibiotics eye drop wasapplied after digital massage on lacrimal system and clean the secret. Grams staining, bacterial cultureand sensitivity test were performed in microbiology laboratory.Result: Clinical and microbiological recovery for chloramfenicol and gentamicin were 43.5% (p = 0.832)and 52.2% (p = 0.670) respectively. The most frequent bacteria on infant dacryocistitis were Staphylococcusaureus (45.7%) followed by Pseudomonas (21.7%), Enterobacter sp (17.4%), Escherichia coli (10.9%) andStaphylococcus epidermidis (4.3%). The sensitivity of bacteria against chloramfenicol and gentamicin was Staphylococcus aureus 57.1%, Pseudomonas aeruginosa 50%, Enterobacter sp 87.5%, Escherichia coli 40%and Staphylococcus epidermidis 100%.Conclusion: There is no significant different between chloramfenicol and gentamicin in dacryocistitis(Sains Medika, 3(2):105-111).

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