Perubahan Histopatologik Pembuluh Darah Aorta dan Kadar Malondiadehyde (MDA) Pada Mus Musculus L. Galur Swiss Derived Akibat Pemberian Minyak Jelantah  

Oleh:

Septian, Akbar ; Thadeus, Maria S. ; Widasari, Lucy

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Bina Widya: Majalah ilmiah UPN "Veteran" Jakarta vol. 24 no. 1 (Dec. 2012), page 6-13.
Topik: Re-used cooking oil; MDA; Lamina Elastic Interna; Aorta Cells

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: BB24.3 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Used cooking oil comes from many different types of cooking oil and has experienced chemical change. The utilization of re-used cooking oil, especially in deep-fring, can result in the creation of toxic free radicals that are harmful for humans. Long period or repeated heating can shorten the usability of the cooking oil due to the increase of the level of peroxide. The type of research is experimental with 12 male Mus musculus L Galur Swiss Derived mencit that given re-used cooking oil orally with a dosage of 10 ul/gr BB and split into 4 groups. Group A is a control groupwith new re-used cooking oil. Group B is given 8-week old re-used cooking oil while grogroup C and D are given 12-week old oil respectively. Application is conducted at the department of pharmacology of FK UPN Veteran, Jakarta. Dissection and sample preparation are done at the anatomical pathology laboratory of FK UI, Jakarta. While the level of malondialdehyde (MDA) in mencit blood is inspected at the laboratory of biochemistry and molecular biology of FK UI, Jakarta. Statistical tests utilized are One Way ANOVA and Spearmen test. The research was conducted from December 2011 to April 2012. Based on the level of change of histopathology, lamina elastic interna aorta in group A did not experience any change, still regular and wavy. Histopathological change was observed occuring from group B while lamina elastic interna aorta was found irregular, and in group C lamina elastic interna aorta was found a straight shape, and in group D lamina elasticinterna aorta was found stripe. The grade of change in lamina elastic of aorta in each group of application time length increased linearly with the level of MDA which in range 0.3-6.4 nmo/ml. And statistic result showed (p<0.05) it means have a meaning significancy. Used cooking oil at a dose of 10ul/g in the use of up to 16 weeks cause internal damage to the aortic lamina elastics Mus musculus and the increasing of malondialdehyde level.

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