Heart Rate Variability and Sensorimotor Polyneuropathy in Type 1 Diabetes  

Oleh:

Orlov, Steven ; Bril, Vera ; Orszag, Andrej ; Perkins, Bruce A. ; Aritonang, John V.L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 35 no. 04 (Apr. 2012), page 809-816 .
Topik: HRV; diabetic sensorimotor polyneuropathy

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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OBJECTIVE Reduced heart rate variability (HRV) is classically viewed as an early phenomenon in diabetic sensorimotor polyneuropathy (DSP). We aimed to determine the characteristics of HRV across the spectrum of clinical DSP in type 1 diabetes. RESEARCH DESIGN AND METHODS Eighty-nine diabetic subjects and 60 healthy volunteers underwent assessment of RR interval variation (RRvar) during deep breathing and clinical and electrophysiological examination. We examined the distribution of age-standardized RRvar across the spectrum of clinical DSP, identified variables associated with RRvar in multivariate regression, and compared RRvar with validated measures of neuropathy. RESULTS Age-standardized RRvar had a significant, step-wise, inverse relationship with ordinal categories of increasing DSP severity (ß = -5.4, P < 0.0001) among subjects with diabetes. Case subjects with DSP had substantially lower age-standardized RRvar compared with diabetic control subjects without DSP (ß = -5.2, P < 0.01), although there was substantial overlap of RRvar between diabetic case subjects and control subjects and the healthy volunteer cohort. In multivariate analysis, advanced age was independently associated with lower RRvar in both healthy volunteers and diabetic subjects, whereas higher glycated hemoglobin A1c and systolic blood pressure were independently associated with lower RRvar in diabetic subjects. RRvar had a significant association with validated measures of large and small fiber neuropathy. CONCLUSIONS HRV may be a biomarker for clinical DSP and is associated cross-sectionally with both early and late measures of neuropathy. The low HRV observed in some control subjects without DSP and in most case subjects with severe DSP may signify that HRV has different prognostic implications in these groups, requiring further longitudinal study.

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