The effect of radioiodine on eradication of Helicobacter pylori infection in patients with thyroid cancer—A pilot study  

Oleh:

Shmuely, Haim ; Friedman, Michael ; Aronov, Igor ; Bernstine, Hanna ; Aritonang, John V.L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Operative Techniques in Otolaryngology Head and Neck Surgery (keterangan: ada di ClinicalKey) vol. 23 no. 03 (Sep. 2012), page 206-210.
Topik: Helicobacter pylori ; Eradication treatment ; Radioactive iodine ; Differentiated thyroid carcinoma ; Hyperthyroidism

Ketersediaan

Perpustakaan FK Nomor Panggil: O07.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Recently, 32% of Helicobacter pylori (H pylori) infected patients who were treated for differentiated thyroid carcinoma (DTC) were found to have a negative urease breath test at 2 months posttreatment. Our objectives were to eradication of clarify equivocal findings, and determine whether radioiodine eradicates this chronic bacterial infection. Twenty-eight patients (25 DTC patients and 3 with hyperthyroidism) positive for H pylori stool antigen were treated with oral radioiodine (131I) at a dose of 100 to 200 mCi in 18 patients with thyroid carcinoma; 30 mCi in 1 patient with a significant residual mass in the thyroid bed after surgery; and 4 mCi in 6 patients who had been treated with 100 to 150 mCi over the last 5 years. The hyperthyroid patients received 10 to 20 mCi. To standardize the results, and better compare with a previous study, only those patients who received a dose of 100 to 200 mCi were included for analysis. All 18 DTC patients who tested positive for H pylori stool antigen before radioiodine treatment remained positive 3 months posttreatment, indicating an eradication rate of 0% with an upper 95% confidence limit of 18.53%. Radioiodine administered to H pylori infected patients did not eradicate infection in Israeli patients.

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