Increasing Airway Smooth Muscle Apoptosis has a Relationship with Increasing CD8* T Cell in Asthmatic Models Mice  

Oleh:

Setiawati, Dessy ; Kusuma, H.M.S Chandra ; Kusworini

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Kedokteran Brawijaya vol. 25 no. 03 (Dec. 2009), page 115-121.
Topik: asthma; mice; ovalbumin; ASM apoptosis and CD8' Tcell

Ketersediaan

Perpustakaan FK Nomor Panggil: J34.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Airway remodeling is an important thing in asthma. The increase of airway smooth muscle mass is a prominent feature of asthmatic airway remodeling. The importance role of airway smooth muscle cell (ASM) apoptosis in airway remodeling is unknown. T cell also had important role in asthma, whereas CD4' T cell role in airway remodeling has already known, but how CD8' T cell role in airway remodeling is still unclear. A randomized control group experimental study used Balb/c mice, that categorized into 2 groups: asthma and control. Asthma group was sensitized by ovalbumin intrapen'toneally in day 0 and 14, followed by inhalation every 2-3 days for 6 weeks. In week 8, all of mice were terminated. The expression of CDS' T cell lymphocyte was examined through immunohistochemistry method, whereas ASM apoptosis by TUN EL method. Independent sample t-test and spearman test was used in statistical analysis with confident interval 95%. The bronchioli and lungs specimens were obtained from 18 mice (9 in each group). Case goup had significant increase in the amount of ASM apoptosis and expression of CD8' T cell lymphocyte (p=0.000; p=0.001). There was also positif correlation between ASM apoptosis and expression of CDS' T cell (r=0.37, p=0.065). We conclude that increasing A SM apoptosis has a relationship with increasing CD8' T cell

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