Vitamin D as Supportive Treatment Improve The Sputum Conversion and Radiographic Finding in Tuberculosis Patients  

Oleh:

Siswanto ; Sumarno ; Jane, Yani ; Widayanti, Oeryana Agustin ; Muktiat, Nunuk Sri

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Kedokteran Brawijaya vol. 25 no. 03 (Dec. 2009), page 128-132.
Topik: pulmonary tuberculosis; sputum conversion; vitamin D; radiographic finding; TNF-a

Ketersediaan

Perpustakaan FK Nomor Panggil: J34.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Pulmonary Tuberculosis remains as a major health problem in South East Asia as well as Indonesia. The failure of tuberculosis treatment is mostly due to drop-out and multiple drugs resistant. Previous study showed that Vitamin D increase the intracellular cathelicidin which has potency to kill the Mycobacterium tuberculosis. This research was aimed to identify the effect of Vitamin D as supportive treatment on the improvement of sputum conversion, radiographic finding and TNF-a serum concentration. A Double-blind randomized control trial was used in two random allocated patient group with standard tuberculosis treatment. The first group was treated with Vitamin D (800 iu/day) while the other was not. Subjects were evaluated using three parameters i.e. sputum conversion, radiographic finding and TNF-a serum concentration. Compared to the group without vitamin D supplementation, group with vitamin D has higher proportion of sputum conversion in the first month (67% vs. 34%, p=0,04) and second month (95% vs. 77%, p=0,18). Improvement in radiographic findings in the group with vitamin D is also higher in the first month (67% vs. 18%, p=0,02) and second month (76% vs. 45%, p=0,06). There is a significant difference in the level of 25-dihidroxyvitamin D between two groups (p=0,00). However, there is no significant difference in the level of TNF-a between two groups (p=0,76) after two months. Vitamin D has supportive effects in pulmonary tuberculosis patients by improving healing process as indicated by faster improvement in sputum conversion and radiographic findings but it did not improve the decrease of TNF-a.

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