Pemberian Fenitoin Oral dan Timbulnya Hiperplasia Ginggiva pada Pasien Epilepsi  

Oleh:

Utomo, Tranggono Yudo ; Husni, Amin ; Hanum, Farichah

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Media Medika Indonesiana vol. 45 no. 03 (Sep. 2011), page 200-205.
Topik: Dosage and duration of phenytoin administration; ginggival hyperplasia

Ketersediaan

Perpustakaan FK Nomor Panggil: M30.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Phenytoin oral treatment and the development of ginggival hyperplasia in epileptic patients Background: Phenytoin is commonly used as a first line drug therapy for epilepsy because of its potency and low cost. Dosage and duration of oral phenytoin administration have been considered as important factors in the development of ginggival hyperplasia. Objective: To investigate whether dosage and duration of oral phenytoin usage were risk factors of ginggival hyperplasia in epileptic patients. Method: Twenty epileptic patiens with phenytoin monotherapy who developed ginggival hyperplasia, and 20 epileptic patients with phenytoin monotherapy without ginggival hyperplasia as a control group were studied. The history of illness, physical examination, fasting and post prandial blood glucose level, funduscopy, oral hygiene, index of hyperplasia scoring from Saymor were taken. Blood sample 3-5 cc were also taken to examine the level of phenytoin. Oral dose, serum dose and duration of administration were noted. Odd ratio was calculated by multiple regression statistic (95% confidence interval). Result: High dose of oral phenytoin was a significant risk factor of ginggival hyperplasia, (p<0.05), while duration of administration >6 months was not a risk factor (p=0.522). Adjusted by duration of oral phenytoin usage, high dose of oral phenytoin usage was still a significant risk factor for gingival hyperplasia, OR=29.14 (95%CI 3.8-291.9). Conclusion: High dose of phenytoin was a significant risk factor for ginggival hyperplasia.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali