Preparat Anti Jamur Dalam Pencegahan Mukositis Oral Akibat Efek Samping Radioterapi pada Pasien Keganasan Kepala Leher  

Oleh:

Kartikawati, Henny

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Media Medika Indonesiana vol. 45 no. 03 (Sep. 2011), page 163-168.
Topik: Fluconazole; itraconazole; mucositis; radiotherapy

Ketersediaan

Perpustakaan FK Nomor Panggil: M30.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Effect of anti fungal preparations as oral mucositis prevention from radiotherapy side effects in nasopharyngeal carcinoma patients Background: Oral mucositis may lessened food intake and delays the radiation schedule in patients with nasopharyngeal carcinoma. Antifungal treatment fluconazole is known to be effective for treating fungal infections of mucous membrane and systemic infections caused by Candida sp. Itraconazole is also effective in treating fungal infections of mucous membrane or systemic infections. This study proves the effectiveness of fluconazole and itraconazole in the prevention of moderate to severe mucositis. Methods: An experimental study design with pre and post test randomized-control trial. Group A1 received fluconazole as prophylactic treatment, group A2 received itraconazole as prophylactic treatment. Group B was as control or non-prophylaxis. The treatment was given from day 11 to day 26 of radiotherapy (for 3 weeks). The outcome of this study was the incidence of moderate to severe mucositis and the findings of Candida Sp. on moderate to severe mucositis using KOH examination. Results: Moderate to severe mucositis was found in 6 cases in the control group (75%), markedly more than the prophylactic fluconazole group with only 2 cases (25%). The incidence of moderate to severe mucositis was also fewer in the itraconazole group, with only 8 cases (36.36%) compared to control group with 15 cases (68.18%). Examination using KOH showed positive fungal infection was greater in the control group compared to fluconazole and itraconazole groups. Conclusion: Fluconazole and itraconazole are useful in preventing the occurrence of moderate to severe mucositis as the side effects of radiotherapy in nasopharyngeal carcinoma patients, with relative risk reduction (RRR) of 40% for fluconazole and 45.8% ofitraconazole.

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