Ekstrak Herbal (Daun Salam, Jintan Hitam, Daun Seledri) dan Kadar IL-6 Plasma Penderita Hiperurisemia  

Oleh:

Ngestiningsih, Dwi ; Hadi, Suyanto

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Media Medika Indonesiana vol. 45 no. 02 (May 2011), page 113-117.
Topik: IL-6; Eugenia polyantha; Apium graveolens; Nigella sativa

Ketersediaan

Perpustakaan FK Nomor Panggil: M30.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Herbal extract (Eugenia polyantha, Nigella sativa, Apium graveolens) and IL-6 plasma level of hyperuricaemic patients Background: Hyperuricaemia stimulates pro-inflammatory cytokines like TNF-a, IL-1 and IL-6. They also will stimulate leucocyte adhesion molecule. Suplementation of bay-leaf (Eugenia polyantha), celery herb (Apium graveolens) and blackseed (Nigella sativa) had known to decrease inflammatory cytokines response including IL-6 blood level. These herbal are common in Indonesia but have not clinically studied correlation with IL-6 pro inflammatory cytokine in human. The aim study was to determine the effect of herbal extract on IL-6 blood level of hyperuricaemic patients. Methods: This study was an experimental study with double blind randomised clinical trial, held on 2007 March–2008 February. Samples were hyperuricaemic patiens in clinic and wards of internal medicine and geriatric RSUP Dr. Kariadi Semarang. They were divided into 2 groups: (1) Extract herbal and (2) placebo group. IL-6 blood level were tested before and 4 weeks after treatment using ELISA methode. Results: Subjects were 43 hyperuricaemic patients (22 in herbal treatment group compare with 21 in placebo group). The mean of basic IL-6 level in herbal group was 214.58 pg/dl whereas in placebo was 182.89 pg/dl. The mean of outcome IL-6 level in herbal group was 192.15 pg/dl whereas in placebo group was 254,00 pg/dl. The mean of IL-6 delta level in herbal group was -22.43 pg/dl whereas in placebo was 71.11 pg/dl (p:0.045). The mean of IL-6 ratio in herbal group was 1142.16% whereas in placebo was 754.45% (p:0.052). Conclusion: The herbal extract being used uric acid lowering agent decreases IL-6 level.

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