Comparison of the Effect of Nebulization between Salbutamol and Salbutamol Diluted with Normal Saline in Adult Patient with Moderate Asthma Exacerbation in Persahabatan Hospital  

Oleh:

Idrus, Indri Savitri ; Yunus, Faisal ; Andarini, Sita Laksmi ; Setiawati, Arini

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Respirologi Indonesia vol. 32 no. 3 (Jul. 2012), page 167-177.
Topik: Moderate asthma exacerbation; salbutamol; normal saline
Fulltext: Comparison of the Effect of Nebulization.pdf (87.43KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: J48.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Asthma is a chronic airway disease that causes difficulty in breathing in which bronchospasm is a hallmark in acute exacerbation. In management of asthma attack, agonist ß2 is the best option as treatment for mild, moderate and severe asthma. Agonist ß2 nebulization as bronchodilator has been used widely nowadays. Lack of clinical study have been done to compare the pharmacological effect of salbutamol nebulization with salbutamol combined with 0.9% sodium chloride for the asthma treatment. The aim of this study was to compare salbutamol nebulization vs salbutamol diluted in 0.9% sodium chloride in adult asthma patients. Methods: Sixty patients with moderate asthma were randomized into 2 groups. First group received diluted 2.5 mg salbutamol nebulization with normal saline and the second group had 2.5 mg undiluted salbutamol. All treatments were carried out in double blind fashion in which the subject & clinical team unable to find out the intervention they had. Results: Baseline characteristics were similar between 2 groups (p > 0.05). In group I which were receive diluted salbutamol found significant decrease in oxygen saturation starting 40 minute after nebulization compared with group II (p<0.001). Cough and easier expectoration were more frequent in group I compared with group II (p < 0.001). Conclusion: There is no different in management moderate asthma with nebulization diluted salbutamol compared salbutamol alone. Diluted salbutamol found significant decreased for oxygen saturation start 40 minute after nebulization. In group with nebulization diluted salbutamol complain cough more frequent and easier expectoration compared with group with nebulization salbutamol alone.

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