Characteristics Vascular Endhothelial Growth Factor, Glucose, Lactate Dehidro- genase and Protein Level in Non Malignant and Malignant Pleural Effusion  

Oleh:

Satolom, Magy ; Muktiati, Nunuk Sri ; Maharani, Asri ; Putra, Ngakan Putu Parsama

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Respirologi Indonesia vol. 32 no. 3 (Jul. 2012), page 146-154.
Topik: pleural effusion; VEGF; glucose; LDH; protein.
Fulltext: Characteristics Vascular Endhothelial.pdf (74.44KB)

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Perpustakaan FK Nomor Panggil: J48.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Introduction: Diagnosing the etiology of pleural effusion is sometimes a challenging medical problem, and there is an urgent need to identify new fluid markers to differentiate malignant from non malignant pleural effusion. The aim of this study was to determine the characteristics of VEGF, glucose, LDH, and protein level in diagnosing of pleural effusion. Methods: Design of this study was observational analytic cross sectional. Undiagnosed unilateral pleural effusion were unrolled and divided into two groups: non malignant and malignant effusions based on cytology analysis. VEGF, glucose, LDH, protein level were measured in pleural fluid. VEGF were measured using ELISA. Results: Of 32 subjects, the median level of VEGF in malignant (3.3818) higher than that in non malignant (2.5844) (p=0.007). No significant differences were observed between VEGF in malignant effusions due to lung cancer and from extra-thoracic cancer (p=0.079). Among all variables evaluated, logistic regression found that only VEGF was significantly correlated with the prescence of malignant disease (p=0.043). Conclusions: Level of VEGF in malignant pleural effusion higher than in non malignant pleural effusion.

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