The effect of prednisone on sertoli cell of contralateral testicular torsion  

Oleh:

Tanuwidjaja, Dandy ; Sugandi, Suwandi ; Sihombing, Aaron Tigor ; Yantisctiasti, Anglita

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Jurnal Urologi Indonesia (Indonesian Journal of Urology) vol. 19 no. 02 (Jul. 2012), page 64-67.
Topik: Prednisone; unilateral testicular torsion; Sertoli cell.

Ketersediaan

Perpustakaan FK Nomor Panggil: J33.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To evaluate the effect of prednisone in unilateral testit it iar torsion on Sertoli cell quality of contralateral testis. Material & Method: Thirty Wis tar rats were divided into three groups i.e. group A (sham procedure), group B (unilateral torsion + orchiectomy after 6 hours), and group C (unilateral ton ion + orchiectomy after 24 hours). Group B and C were further divided into subgroup with and without Prednisone administration. Prednisone was given orally once a day an how-after torsion, continued till one month later. Orchiectomy of cof'tilateral testis was performed one'month later. Those testes were examined by a pathologist. Results: In group A. no normality on Sertoli cell quality was found. There is significant difference among groups in Sertoli cell quality (p =t).i-, Ischenm time is associated with Sertoli cell quality (2 rats with severe damage in group C and none in group B). In grottj and C, prednisone administration inhibited Sertoli cell damage. Prednisone administration in 6 hours group gave betH • results than 24 hours group (3 rats vs I rat with good Sertoli cell quality). Conclusion: Sertoli cell in contralateral testis is significantly affected by unilateral testicular torsion. Prednisone inhibit Sertoli cells damage. Ischemic time affected St noli cell quality of contralateral testis and respond to prednisone.

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