Effect of IV Injection of Radiographic Contrast Media on Human Renal Blood Flow  

Oleh:

Hackstein, Nils ; Schneider, Christian ; Eichner, Gerrit ; Rau, Wigbert S.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: American Journal of Roentgenology vol. 188 no. 05 (May 2007), page 1367-1372 .
Topik: GENITOURINARY IMAGING; Contrast-induced nephropathy; contrast media; hemodynamics; kidney; MR technique; renal disease

Ketersediaan

Perpustakaan FK Nomor Panggil: A13.K.2007.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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OBJECTIVE. The purpose of our study was to assess the effect of an IV injection of iodinated radiographic contrast medium on human renal blood flow using cine phase-contrast MRI. SUBJECTS AND METHODS. We examined 12 healthy adult volunteers. Blood flow in one renal artery was measured using cine phase-contrast imaging (1.5-T MR system). Each volunteer received 120 mL of isotonic sodium chloride on study day 1 and 120 mL of a low-osmolar, nonionic, iodinated contrast medium (iomeprol, 400 mg I/mL) on study day 2. Repetitive measurements were performed before (up to five measurements in 5 minutes) and after (up to 13 measurements in 30 minutes) the injection was started. RESULTS. Mean basal renal artery blood flow was 664 mL/min. In response to the injection of the test substances, we found a significantly larger decrease in average renal blood flow for contrast medium than for sodium chloride (31.9 mL/min vs 18.3 mL/min, p = 0.0481). Furthermore, in analyzing the measurements at early time points, we found a significant decrease (11.4% ± 4.7% [SD]; Bonferroni-corrected, p < 0.05) in renal blood flow 2 minutes after the injection of the contrast medium was started. Sodium chloride did not produce a significant effect at any time. CONCLUSION. Cine phase-contrast MRI can measure a decrease in renal blood flow in humans in response to an IV injection of iodinated radiographic contrast medium. Therefore, cine phase-contrast MRI can be a helpful and noninvasive tool for further investigations of contrast media-induced changes in human renal blood flow and their possible impact on the development of contrast-induced nephropathy.

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