Case Report: Respiratory Bronchiolitis-Associated Interstitial Lung Disease in a Nonsmoker: Radiologic and Pathologic Findings  

Oleh:

Woo, Ok Hee ; Yong, Hwan Seok ; Oh, Yu-Whan ; Lee, Sung Yong

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: American Journal of Roentgenology vol. 188 no. 05 (May 2007), page W412-W414.
Topik: CHEST IMAGING; high-resolution CT; lung diseases; radiologic-pathologic; correlation

Ketersediaan

Perpustakaan FK Nomor Panggil: A13.K.2007.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Respiratory bronchiolitis is a common inflammatory lesion of the respiratory bronchioles that occurs mainly in cigarette smokers. It was first described in 1974 by Niewoehner et al. [1] in an autopsy study of 39 patients who died of nonpulmonary causes. Its histologic appearance is characterized by the accumulation of pigmented macrophages within the respiratory bronchioles and the surrounding airspaces, with minimal associated mural inflammation [1]. In some patients, the extent of alveolar accumulation and bronchiolar inflammation is severe enough to produce clinical, physiologic, and imaging features of interstitial lung disease [2, 3]. This clinicopathologic syndrome, called respiratory bronchiolitis-associated interstitial lung disease (RB-ILD), occurs almost exclusively in heavy cigarette smokers. A small number of cases of cigarette-smoking-associated RB-ILD with positive imaging findings have been reported in the existing literature, but the radiologic findings have not yet been described regarding the occurrence of RB-ILD in nonsmokers. This article reports a case in which radiologic features have a clinical and pathologic correlation to histologically proven RB-ILD in a nonsmoker who was heavily exposed to second-hand smoke.

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