Intramuscular progesterone versus 8% Crinone vaginal gel for luteal phase support for day 3 cryopreserved embryo transfer  

Oleh:

Kaser, Daniel J. ; Ginsburg, Elizabeth S. ; Missmer, Stacey A. ; Correia, Katharine F. ; Sadikin-Susilo

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 98 no. 06 (Dec. 2012), page 1464-1469.
Topik: PREGNANCY; Crinone vaginal gel; intramuscular progesterone; luteal phase support; frozen

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To compare outcomes after intramuscular progesterone (IMP) or 8% Crinone vaginal gel for luteal support for day 3 cryopreserved embryo transfer (CET). Design Retrospective cohort study with multivariable analysis. Setting Academic medical center. Patient(s) All autologous and donor egg in vitro fertilization and intracytoplasmic sperm injection patients who had a day 3 CET from January 1, 2008, to April 30, 2011, with luteal support using 25–50 mg/d IMP or 8% Crinone twice daily, initiated 3 days before the CET. Intervention(s) None. Main Outcome Measure(s) Implantation rate, clinical pregnancy, and live birth rates per CET. Result(s) IMP (n = 440) and Crinone (n = 298) recipients were similar for all demographic characteristics and cycle parameters assessed. Although implantation rates did not differ significantly between the two groups (Crinone vs. IMP: 19.6% vs. 30.4%), women supplemented with Crinone had significantly lower rates of clinical pregnancy (36.9% vs. 51.1%) and live birth (24.4% vs. 39.1%) compared with those on IMP. Conclusion(s) We observed that day 3 CET cycles with 8% Crinone luteal support had a 44% and 49% lower odds of clinical pregnancy and live birth, respectively, compared with those with IMP support. Further studies are required to identify the optimal timing and dose of 8% Crinone vaginal gel for use in CET cycles.

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