Tumor necrosis factor-alpha promoter polymorphisms are associated with idiopathic primary ovarian insufficiency in Korean women  

Oleh:

Kim, Ji Hyang ; Jeon, Young Joo ; Rah, HyungChul ; Lee, Bo Eun

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 98 no. 05 (Nov. 2012), page 1260-1265.
Topik: INFERTILITY; Primary ovarian insufficiency (POI); tumor necrosis factor-a (TNF-a); polymorphism

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To investigate the possible association between primary ovarian insufficiency (POI) and TNF-a gene polymorphisms in Korean women. Design Case–control study. Setting An urban university-based hospital in South Korea. Patient(s) A cohort of 135 Korean POI patients and 236 controls. Intervention(s) None. Main Outcome Measure(s) We analyzed TNF-a gene variants of all participants using the polymerase chain reaction-restriction fragment length polymorphism assay. Result(s) The TNF-a -1031TC+CC, -238GA+AA, -1031TC+CC/-308GG, -1031TT/-308GA+AA, -1031TC+CC/-238GA+AA, and -308GG/-238GA+AA genotypes were significantly more frequent in POI patients than in controls. Among the haplotypes for the three TNF-a loci, the -1031C/-308G/-238A haplotype was more frequent in POI patients than in controls and conferred POI susceptibility. In analyses of two loci, the -1031T/-308A, -1031C/-308G, -1031C/-238A, and -308G/-238A haplotypes were more frequent in POI patients. Conclusion(s) The TNF-a -1031C and -238A alleles had strong association with POI. The TNF-a -308A allele showed limited significance for POI risk with the presence of the -1031T allele. Our data suggest that the minor alleles of TNF-a promoter polymorphisms may increase POI risk in Korean women.

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