Urinary a-carboxyethyl hydroxychroman can be used as a predictor of a-tocopherol adequacy, as demonstrated in the Energetics Study  

Oleh:

Lebold, Katie M. ; Ang, Alfonso ; Traber, Maret G. ; Arab, Lenore

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 96 no. 04 (Oct. 2012), page 801-809 .
Topik: VITAMINS; Minerals; phytochemicals

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2012.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Other than the in vitro erythrocyte hemolysis test, no valid biomarkers of vitamin E status currently exist. Objective: We hypothesized that the urinary vitamin E metabolite a-carboxyethyl hydroxychroman (a-CEHC) could serve as a biomarker. Design: The relations between urinary a-CEHC, plasma a-tocopherol, and vitamin E intakes were assessed by using a previously validated multipass, Web-based, 24-h self-administered dietary recall, and we concurrently collected plasma and 24-h urine samples from 233 participants of both sexes. Results: Median vitamin E intakes were 9.7 mg a-tocopherol/d. Intakes were correlated with plasma a-tocopherol (R = 0.40, P < 0.001) and urinary a-CEHC (R = 0.42, P < 0.001); these correlations were essentially unchanged after multivariate adjustments. On the basis of multiple regression analysis, urinary a-CEHC excretion increased by ~0.086 µmol/g creatinine (95% CI: 0.047, 0.125) for every 1-mg (2.3-µmol) increase in dietary a-tocopherol. Urinary a-CEHC excretion remained at a plateau (median: 1.39 µmol/g creatinine) until dietary intakes of a-tocopherol exceeded 9 mg a-tocopherol/d. The inflection point at which vitamin E metabolism increased was estimated to be at an intake of 12.8 mg a-tocopherol/d. Daily excretion of >1.39 µmol a-CEHC/g creatinine is associated with a greater than adequate a-tocopherol status, as evidenced by increased vitamin E metabolism and excretion. Conclusion: Thus, urinary a-CEHC is a valid biomarker of a-tocopherol status that can be used to set a value for the Estimated Adequate Requirement of vitamin E.

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