Bone microstructure and atomic periodic disharmonization in osteoporosis  

Oleh:

Noor, Zairin ; Hidayat, Mohammad ; Rahim, Agus Hadian

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Universa Medicina vol. 31 no. 02 (May 2012), page 96-104.
Topik: Mineral atoms; composite; microstructure; osteoporosis
Fulltext: Zairin-Noor.pdf (361.62KB)

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Perpustakaan FK Nomor Panggil: U01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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BACKGROUND Both cortical and cancellous bone display a complex, porous microstructure whose properties depend on the macrostructure of bone as well as age and health of the individual. The aim of this study was to compare the microstructure and characteristics of mineral atoms in osteoporotic and normal bone. METHODS A prospective laboratory experimental study was conducted from August to December 2010 at several hospitals in Banjarmasin. Twenty patients with osteoporosis and twenty six normal patients were involved in this study. Bone obtained from surgery was analyzed for microstructure by scanning electron microscopy (SEM), while mapping of mineral atoms was performed by means of SEM-Energy dispersive X-ray spectroscopy (SEM-EDAX) at the Brawijaya University, Malang. RESULTS The osteoporotic subjects with mean age of 64.65 ± 16.41 years were older than the normal bone subjects with mean age of 39.38 ± 17.16 years. The body mass index was similar in both groups of subjects. From SEM-EDAX results, three patterns of mineral atoms were apparent in osteoporotic and normal bone. In osteoporotic bone, these patterns were indicative of a disordered substitution or incorporation process. SEM results showed degeneration of microarchitecture (resorption cavities, perforations, and prominent granules) in osteoporotic but not in normal bone. There was a significant difference in microstructure between osteoporotic and normal bone, which was caused by differences in atomic properties. CONCLUSIONS Microstructural abnormalities of bone and disharmonization of mineral atoms in the periodic system were found in osteoporosis.

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