Serum 8-isoprostane increased in pre-eclampsia  

Oleh:

Pramono, Besari Adi ; Kristanto, Herman

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Universa Medicina vol. 31 no. 01 (Jan. 2012), page 43-51.
Topik: 8-Isoprostane level; birth weight; pre-eclampsia
Fulltext: Besari1.pdf (50.89KB)

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Perpustakaan FK Nomor Panggil: U01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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BACKGROUND The main causes of maternal mortality in Indonesia are pre-eclampsia,hemorrhage, and infection. Oxidative stress has a primary role in pre-eclampsiaand one of its parameters is 8-isoprostane serum level. The objective of thisstudy is to measure 8-isoprostane and to analyze the relationship between 8-isoprostane level and birth weight in pre-eclampsia.METHODSA cross-sectional study involving 23 pre-eclampsia and 29 normotensivepregnant women with normal or cesarean delivery at Dr. Kariadi HospitalSemarang from January to May 2011. Collected maternal blood samples wereassessed for 8-Isoprostane levels by means of a specific ELISA kit. Neonatalbirth weight was measured immediately after delivery by means of calibratedbaby scales. Differences in 8-isoprostane levels between pre-eclampsia andnormotensive women were assessed using independent t-test for normaldistributed data, and the Mann-Whitney test for non-normally distributed data. RESULTS Mean 8-isoprostane level was significantly higher in women with pre-eclampsiathan in normotensive women (62.52 ± 12.19 pg/mL vs 28.64 ± 8.81 pg/mL)(p<0.05). Low birth weight was twice as frequent in pre-eclampsia than innormotensives. There was no correlation between 8-isoprostane serum leveland neonatal birth weight in pre-eclampsia. CONCLUSION The level of 8-isoprostane was higher in pre-eclampsia than in normotensives.It is recommended to conduct further studies to determine whether 8-isoprostanemay be used as a predictive marker of pre-eclampsia.

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