Screening of Actinomycetes Producing an ATPase Inhibitor of RNA Helicase from Soil and Leaf Litter Samples  

Oleh:

Ratnakomala, Shanti ; Ridwan, Roni ; Lisdiyanti, Puspita ; Abinawanto ; Utama, Andi

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Microbiology Indonesia vol. 5 no. 1 (Mar. 2011), page 15-20.
Topik: actinomycetes; JEV; RNAhelicase; inhibitor; Japanese encephalitis virus
Fulltext: 2_her.pdf (83.2KB)

Isi artikel

Actinomycetes are commercially important microorganisms for the production of antibiotics, enzymes, inhibitors of enzymes, and other bioactive secondary metabolites. Some 853 isolates of actinomycetes were isolated from soil and leaf litter samples in Kupang NTT and Enrekang, South Sulawesi. Those isolates were then tested for inhibition ofATPase activity of RNA helicase from Japanese encephalitis virus (JEV), in order to identify a drug candidate for the treatment of JEV infection. Results revealed that 14 isolates have relatively high inhibition-activity on JEVATPase activity of the JEV-RNAhelicase, which range from approximately 40.0-50.0% inhibition. The highest inhibition-activity was identified in Actinoplanes philippinensis 5-849 with 49. 9% of inhibition-activity and Streptomyces chartreusis 5-095 with 49.2% of inhibition-activity.

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