Detail Secretome as neuropathology-targeted intervention of Parkinson’s disease (Article of Regenerative Theraphy Vol. 21 Agustus 22 p. 288-293) Bibliografi Author: Ardianto, Christian ; Shen, Robert ; Barus, Jimmy Fransisco Abadinta ; Sasmita, Poppy Kristina ; Turana, Yuda ; Lilis ; Sidharta, Veronika Maria Topik: Mesenchymal stem cell; Molecular targeted therapy; Neurodegenerative disease; Regenerative medicine; Synucleinopathy Bahasa: (EN )     Penerbit: Elsevier     Tahun Terbit: 2022     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: B7 Secretome as neuropathology-targeted intervention of Parkinson’s.pdf (595.53KB; 2 download) Abstract Parkinson's disease (PD) is the second most common progressive neurodegenerative disease, characterized by apoptosis of dopaminergic neurons in substansia nigra pars compacta (SNpc) caused by ?-synuclein aggregation. The use of secretomes released by medicinal signaling cells (MSCs) is one the promising preventive approaches that target several mechanisms in the neuropathology of PD. Its components target the lack of neurotrophin factors, proteasome dysfunction, oxidative stress, mitochondrial dysfunction, and at last neuroinflammation via several pathways. The complex and obscure pathology of PD induce the difficulty of the search of potential preventive approach for this disease. We described the potential of secretome of MSC as the novel preventive approach for PD, especially by targeting the said major pathogenesis of PD. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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