Detail The Association between Metabolic Dysfunction-Associated Fatty Liver Disease and Chronic Kidney Disease: A Systematic Review and Meta-Analysis (Article of Diabetes & Metabolic Syndrome: Clinical Research & Reviews Vol. 17 2023 p. 1-10) Bibliografi Author: Agustanti, Nenny ; Soetedjo, Nanny Natalia Mulyani ; Damara, Fachreza Aryo ; Iryaningrum, Maria Riastuti ; Permana, Hikmat ; Bestari, Muhamad Begawan ; Supriyadi, Rudi Topik: Chronic kidney disease; MAFLD; NAFLD Bahasa: (EN )     Penerbit: Elsevier     Tahun Terbit: 2023     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: B3. Publikasi.pdf (1.16MB; 2 download) Abstract Background and aims: The term metabolic dysfunction associated fatty liver disease (MAFLD) has been established to better de?ne patients with fatty liver disease who also present with metabolic dysfunction. However, the association between MAFLD and chronic-kidney disease (CKD) remains elusive. Methods: We conducted systematic literature searching across multiple databasesePubMed, EMBASE, Cochrane library, and Google Scholar up until June 9th, 2022. The main exposure was the diagnosis of MAFLD and nonalcoholic fatty liver disease (NAFLD) regardless of the diagnostic modalities being used. The outcome of interest was the prevalence or the incidence of CKD. Results: There were 355,886 subjects from 11 included studies with the period of follow up of 4.6e6.5 years. Meta-analysis of cross-sectional studies showed that MAFLD was associated with a higher prevalent CKD (OR 1.50, 95%CI [1.02e2.23]; test for overall effect Z ¼ 2.04, p ¼ 0.04; I2 ¼ 97.7%, p < 0.001) and incident CKD (adjusted HR 1.35, 95%CI [1.18e1.52]; test for overall effect Z ¼ 15.47, p < 0.001; I ¼ 84.6%, p < 0.001) and did not vary between age, sex, comorbidities, study region, and follow-up duration. No difference in CKD prevalence was found between MAFLD and NAFLD patients. Signi?cant liver ?brosis, but not steatosis in was associated with greater odds of developing CKD. More severe MAFLD was also associated with higher odds of developing CKD. Conclusion: This present meta-analysis using a large population indicates a signi?cant association between MAFLD and the prevalence and incidence of CKD. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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