a-Lactalbumin and Casein-Glycomacropeptide Do Not Affect Iron Absorption from Formula in Healthy Term Infants  

Oleh:

Szymlek-Gay, Ewa A. ; Lonnerdal, Bo ; Abrams, Steven A. ; Kvistgaard, Anne S.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JN: The Journal of Nutrition vol. 142 no. 07 (Jul. 2012), page 1226-1231.
Topik: NUTRIENT; Metabolism; Nutrient-Nutrient Interactions; Mineral Absorption

Ketersediaan

Perpustakaan FK Nomor Panggil: J42.K.2012.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Iron absorption from infant formula is relatively low. a-Lactalbumin and casein-glycomacropeptide have been suggested to enhance mineral absorption. We therefore assessed the effect of a-lactalbumin and casein-glycomacropeptide on iron absorption from infant formula in healthy term infants. Thirty-one infants were randomly assigned to receive 1 of 3 formulas (4 mg iron/L, 13.1 g protein/L) from 4–8 wk to 6 mo of age: commercially available whey-predominant standard infant formula (standard formula), a-lactalbumin–enriched infant formula (a-LAC), or a-lactalbumin–enriched/casein-glycomacropeptide–reduced infant formula (a-LAC/RGMP). Nine breast-fed infants served as a reference. At 5.5 mo of age, 58Fe was administered to all infants in a meal. Blood samples were collected 14 d later for iron absorption and iron status indices. Iron deficiency was defined as depleted iron stores, iron-deficient erythropoiesis, or iron deficiency anemia. Iron absorption (mean ± SD) was 10.3 ± 7.0% from standard formula, 8.6 ± 3.8% from a-LAC, 9.2 ± 6.5% from a-LAC/RGMP, and 12.9 ± 6.5% from breast milk, with no difference between the formula groups (P = 0.79) or all groups (P = 0.44). In the formula-fed infants only, iron absorption was negatively correlated with serum ferritin (r = -0.49; P = 0.005) and was higher (P = 0.023) in iron-deficient infants (16.4 ± 12.4%) compared with those with adequate iron status (8.6 ± 4.4%). Our findings indicate that a-lactalbumin and casein-glycomacropeptide do not affect iron absorption from infant formula in infants. Low serum ferritin concentrations are correlated with increased iron absorption from infant formula.

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