Dietary intake of PUFAs and colorectal polyp risk  

Oleh:

Murff, Harvey J. ; Shrubsole, Martha J. ; Cai, Qiuyin ; Smalley, Walter E.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 95 no. 03 (Mar. 2012), page 703-712.
Topik: PUBLIC HEALTH; Nutritional Epidemiology; Prostaglandins E; Polyunsaturated Fatty Acids; Colonoscopy; Polyp Colorectal; Diet; Adenomatous Polyps; Biological Markers; Polyps; Urinary Tract; Risk Reduction; Polyp; Metaplastic Adenoma Of Large Intestine
Fulltext: A07 v95 n3 p703 kelik2022.pdf (213.81KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2012.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Marine-derived n-3 (omega-3) PUFAs may reduce risk of developing colorectal cancer; however, few studies have investigated the association of n-3 PUFA intakes on colorectal polyp risk. Objective: The objective of this study was to examine the associations of dietary PUFA intake on risk of colorectal adenomatous and hyperplastic polyps. Design: This was a colonoscopy-based case-control study that included 3166 polyp-free control subjects, 1597 adenomatous polyp cases, and 544 hyperplastic polyp cases. Dietary PUFA intake was calculated from food-frequency questionnaires and tested for association by using unconditional logistic regression. The urinary prostaglandin E2 metabolite, which is a biomarker of prostaglandin E2 production, was measured in 896 participants by using liquid chromatography and tandem mass spectrometry. Results: n-6 PUFAs were not associated with adenomatous or hyperplastic polyps in either men or women. Marine-derived n-3 PUFAs were associated with reduced risk of colorectal adenomas in women only, with an adjusted OR of 0.67 (95% CI: 0.47, 0.97) for the highest quintile of intake compared with the lowest quintile of intake (P-trend = 0.01). Dietary intake of a-linolenic acid was associated with an increased risk of hyperplastic polyps in men (P-trend = 0.03), which was not seen in women. In women, but not in men, dietary intake of marine-derived n-3 PUFAs was negatively correlated with urinary prostaglandin E2 production (r = -0.18; P = 0.002). Conclusion: Higher intakes of marine-derived n-3 PUFAs are associated with lower risk of adenomatous polyps in women, and the association may be mediated in part through a reduction in the production of prostaglandin E2.

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