Determinants of urinary methylmalonic acid concentration in an elderly population in the United Kingdom  

Oleh:

Flatley, Janet E ; Garner, Clare M. ; Al-Turki, Maha ; Manning, Nigel J.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 95 no. 03 (Mar. 2012), page 686-693.
Topik: Aging; PENUAAN; Renal Function; Creatinine; Diet; Biological Markers; Life Style; Methylmalonic Acid; Plasma; Urinary Tract; Vitamin B12; Renal Impairment; Older Adult; Gastric Function
Fulltext: A07 v95 n3 p686 kelik2022.pdf (148.85KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2012.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: An age-related deterioration of vitamin B-12 status has been well documented. The early detection of deficiency may prevent the development of serious clinical symptoms, but plasma vitamin B-12 concentration is known to be an imperfect measure of vitamin B-12 status. Urinary methylmalonic acid (MMA) may be a more informative biomarker of vitamin B-12 status; however, biochemical, dietary, and other lifestyle determinants are not known. Objective: We identified determinants of urinary MMA concentrations in free-living men and women aged =65 y in the United Kingdom. Design: A cross-sectional study in 591 men and women aged 65–85 y, with no clinical evidence of vitamin B-12 deficiency, was conducted to determine the demographic, clinical, and lifestyle determinants of urinary MMA concentration expressed as the ratio of micromoles of MMA to millimoles of creatinine (uMMA ratio). Results: Twenty percent of subjects had plasma vitamin B-12 concentrations <200 pmol/L. Seventeen percent of the variation in the uMMA ratio could be explained by plasma holotranscobalamin and sex; total vitamin B-12 intake and measures of renal function and gastric function made only a small contribution to the model. The uMMA ratio was lower in people with moderately impaired renal function. Conclusions: Plasma holotranscobalamin and sex were the most important determinants of uMMA ratio in elderly people with no clinical diagnosis of renal impairment. This biomarker might underestimate vitamin B-12 deficiency in a population in which renal impairment is prevalent.

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