The metabolic effects of di (2-ethyl hexyl) phthalate medium dose on lipid profi les in serum and liver tissue  

Oleh:

Buang Y.

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Medical Journal of Indonesia vol. 20 no. 01 (Feb. 2011), page 20-26.
Topik: Di (2-ethyl hexyl) phthalate; hyperphospholipids; lipolysis; liver lipids; serum lipids
Fulltext: Volume 20, Issue 1, February 2011 - The metabolic effects of di (2-ethyl hexyl) phthalate medium dose on lipid profi les in serum and liver tissue.pdf (465.77KB)

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Perpustakaan FK Nomor Panggil: M35.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Methods: Sprague Dawley rats were fed 1.0 % di (2-ethyl hexyl) phthalate diet (DEHP group, n=5) or a non-supplemented diet (control group, n=5) for 10 days. The rats were allowed to freely access each food. Serum lipid concentrations were measured using enzyme assay kits. Lipids of liver tissues were extracted and the lipid contents were determined. A peach of liver was prepared to determine the activities of malic enzyme and carnitine palmitoyl transferase-1 (CPT-1). Results: Serum lipid concentrations (mg/dL) of DEHP group decreased compared to control (P<0.05). The serum triglyceride (TG) concentrations of control and DEHP groups were respectively (100.5±16.5) and (31.2±1.7); phospholipid (PL), (143.3±7.8) and (88.9±3.2); total cholesterol, (88.7±4.6) and (51.9±2.3). The liver TG content of control and DEHP group (mg/g liver) were respectively, (40.8±4.4) and (23.7±1.3); liver cholesterol were (3.36±0.29) and (2.33±0.23); and the liver PL were (36.5±1.0) and (41.7±0.6). Malic enzyme and CPT-1 activities (nmol/min/ mg protein) of DEHP group increased compared to control (P<0.05), in which their increases were approximately by 4.35- and 2.33-folds, respectively. Conclusion: The di (2-ethyl hexyl) phthalate medium dose attenuates lipids secretion from the liver cells into the bloodstream. The increase of liver PL level accompanied with the promotions of malic enzyme and the CPT-1 activities are the key factors of the dietary di (2-ethyl hexyl) phthalate effects in rats to attenuate the lipid secretions from the livers

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