Premature birth and low birthweight are associated with a lower rate of reproduction in adulthood: a Swedish population-based registry study  

Oleh:

deKeyser, N. ; Josefsson, A. ; Bladh, M. ; Carstensen, J.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Human Reproduction vol. 27 no. 04 (Apr. 2012), page 1170-1178.
Topik: REPRODUCTIVE EPIDEMIOLOGY; Fetal Growth Retardation; Infertility; Low Birthweight; Premature Birth; Reproduction

Ketersediaan

Perpustakaan FK Nomor Panggil: H07.K.2012.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

BACKGROUND The aim of this study was to investigate if individuals born with sub-optimal birth characteristics have reduced probability of reproducing in adulthood. METHODS Using population-based registries, the authors included 522 216 males and 494 692 females born between 1973 and 1983 and examined their reproductive status as of 2006. Outcome measure was the hazard ratio (HR) of reproducing. Adjustments were made for socio-economic factors. RESULTS Males and females born very premature displayed a reduced probability of reproducing [HR = 0.78, 95% confidence interval (CI): 0.70–0.86 for males; HR = 0.81, CI: 0.75–0.88 for females]. Likewise for very low birthweight (HR = 0.83, CI: 0.71–0.95 for males; HR = 0.80, 95% CI: 0.72–0.89 for females). Individuals born large for gestational age (LGA) displayed no significant changes. Males born small for gestational age (SGA) had a 9% lower reproductive rate (CI: 0.89–0.94) and that reduction increased as the individuals aged. Women born SGA tended to start reproducing at an earlier age. CONCLUSION The results suggest that being born with low birthweight, premature or SGA (for males) is associated with a reduced probability of reproducing as an adult. LGA shows no statistically significant relationship with future reproduction.

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