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Intestinal Amyloidosis in A Patient with Crohn's Disease: A Rare Case Report (presented at Asian Pacific Digestive Week APDW Kolkata, 11-15 December 2019, article of Journal of Gastroenterology and Hepatology Vol.34 Supp.3 Dec 2019)
Bibliografi
Author:
CHRISTY, KEZIA
;
Herbert, Harold
;
Purnomo, Sugiharto
;
Tenggara, Riki
Topik:
Amyloidosis
;
Crohn's Disease
;
Bowel obstruction
;
JABFUNG-FKIK-RTG-2021-15
Bahasa:
(EN )
Penerbit:
Wiley
Tempat Terbit:
Kolkata
Tahun Terbit:
2019
Jenis:
Papers/Makalah - pada seminar internasional
Fulltext:
B-15 Dokumen.pdf
(3.44MB;
1 download
)
Abstract
Background and aims
Amyloidosis results from a deposit of insoluble fibrillar protein aggregate that may cause a disruption of normal structure and function of organs and tissues. Secondary amyloidosis is very rare, for example Crohn’s disease, which made a thorough studies impossible. We presented a case report of 34 years old man with secondary amyloidosis caused by Crohn’s disease.
Methods
A retrospective chart review was performed on a single patient.
Results
A 34-year-old man was admitted to the hospital with abdominal pain and small bowel obstruction, the patient is still taking tuberculosis medication. Seven months before admission, he was diagnosed with pulmonary tuberculosis based on the sputum acid fast stain test. Three months later, he had admitted with constipation and threw up several times. He was performed abdominal X-ray, which showed small bowel obstruction. He was referred to a surgeon but he refused to take any surgery. On admission, the patient presented with abdominal enlargement and signs of obstruction and stable vital signs. He had severe malnourished and lost 10 kg in 3 months. Physical examination showed distended abdomen with signs of bowel obstruction. Complete blood count, serum electrolytes, liver function tests, coagulation, and renal function tests were done. Hypoalbuminemia and elevated liver enzyme was observed. No other organ failure was detected. The patient underwent laparotomy and multiple skip lesion with stenosis thought to be crohn's disease was found. Ileum and transverse colon bypass was performed to reduce the risk of bowel obstruction recurrence. The pathology specimen showed deposition of amyloid of the terminal ileum walls. The patient was discharged from the hospital in stable condition in 7 days after surgery.
Conclusions
Secondary amyloidosis and inflammatory bowel disease, such as Crohn’s disease, has been associated even though it is rare.
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