Investigation of systemic inflammatory response in first trimester pregnancy failure  

Oleh:

Calleja-Agius, J. ; Jauniaux, E. ; Pizzey, A.R. ; Muttukrishna, S.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Human Reproduction vol. 27 no. 02 (Feb. 2012), page 349-357.
Topik: EARLY PREGNANCY; Cytokines; Miscarriage; Inflammation

Ketersediaan

Perpustakaan FK Nomor Panggil: H07.K.2012.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

BACKGROUND The contribution of local and systemic inflammation to the pathophysiology of sporadic first trimester miscarriages remains unclear. The objective of this study was to investigate the inflammatory response in the circulation of women presenting with first trimester miscarriage. METHODS Levels of tumour necrosis factor alpha (TNFa), TNF receptors 1 and 2, interferon gamma (IFN?), interleukin (IL)-6 and IL-10 were assayed using cytometric bead arrays in plasma samples from 29 euploid and 21 aneuploid missed miscarriages, 35 normal pregnant controls and 31 non-pregnant women (NPW). Whole blood flow cytometry was carried out with samples from 17 euploid and 16 aneuploid miscarriages, 18 pregnant controls and 13 NPW. RESULTS The plasma of women with euploid miscarriage contained significantly higher circulating levels of TNFa (P < 0.005), IFN? (P < 0.005), IL-6 (P < 0.005) and IL-10 (P < 0.01) than that of pregnant controls, irrespective of gestational age. Significantly (P < 0.05) higher TNF-R1 levels at 6–9 weeks, and significantly higher TNFa/IL-6 (P < 0.001) and significantly lower TNFa/IL-10 (P < 0.001) and IFN?/IL-10 (P < 0.001) ratios at 10–14 weeks, were also found in euploid miscarriage cases compared with pregnant controls. TNFa/IL-10 ratio in plasma was significantly (P < 0.05) lower in miscarriages with an abnormal karyotype than those with normal karyotype. Normal pregnant women had a significantly higher plasma level of IFN? (P < 0.01) and IFN?/IL-10 ratio (P < 0.005), a significantly (P < 0.005) lower TNF-R1 level, and a significant (P < 0.05) increase in stimulated TNFa in monocytes, compared with NPW. CONCLUSIONS Our data confirm that there is an inflammatory reaction in normal pregnancy compared with the non-pregnant state, which may be disrupted during miscarriage.

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