Cerebrospinal Fluid Levels of Soluble Amyloid Precursor Protein and ß-Amyloid 42 in Patients with Multiple Sclerosis, Neuromyelitis Optica and Clinically Isolated Syndrome  

Oleh:

Mai, W. ; Hu, X. ; Lu, Z. ; Peng, F. ; Wang, Y.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 39 no. 06 (Nov. 2011), page 2402-2413.
Topik: Multiple Sclerosis; Neuromyelitis Optica; Clinically Isolated Syndrome; Axonal Damage; Amyloid Precursor Protein; ?-Amyloid 42

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Amyloid precursor protein (APP) accumulation in axonal ovoids is a sensitive marker for acute axonal injury in multiple sclerosis (MS) lesions. This study measured levels of a-cleaved soluble APP (a sAPP) and ß-amyloid 42 (Aß42) in the cerebrospinal fluid (CSF) of 42 MS, 10 neuromyelitis optica and 25 clinically isolated syndrome patients and 21 healthy controls, and analysed the correlation between asAPP and Aß42 levels and relevant clinical parameters. The CSF concentrations of asAPP and Aß42 in patients and controls were not significantly different. There was a significant inverse correlation in patientsbetween CSF asAPP concentration and the Expanded Disability Status Scale (EDSS), but no significant correlation between CSF Aß42 concentration and EDSS. The concentration of asAPP in the CSF of statin-treated patients was significantly higher than in those not treated with statins, suggesting that statins may have a neuroprotective effect. In conclusion, asAPP was present at similar levels in the CSF of patients with neuromyelitis optica, MS and clinically isolated syndrome and healthy controls, and an inverse correlation existed between CSF asAPP concentration and neurological disability.

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