Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes  

Oleh:

Munne, Santiago ; Held, Karsten R. ; Magli, Cristina M. ; Ata, Baris

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 97 no. 04 (Apr. 2012), page 935-942.
Topik: PGD; Preimplantation Genetic Diagnosis; Aneuploidy; Cryopreservation; Fertility Preservation; Cancer; PGS

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To determine the extent of intra-age and intercycle variations in the frequency of first polar body aneuploidy in two consecutive cycles of oocyte retrieval undertaken by the same patient within 1 year. Design Retrospective study. Setting Fertility centers. Patient(s) Infertile couples undergoing IVF. Intervention(s) Patients underwent two consecutive cycles of preimplantation genetic screening through first polar body biopsy within 1 year. Main Outcome Measure(s) Meiosis I aneuploidy. Result(s) A total of 226 patients underwent 452 cycles of preimplantation genetic screening. Differences within age groups were wide, with 0–100% of oocytes being chromosomally normal in all age groups. Euploidy rates between centers were significantly different (48% vs. 25%). Intercycle differences for the same patient were also wide (0–100%), but with 68.5% of patients having less than ±2 euploid eggs of difference between cycles. Conclusion(s) Although euploidy rate decreased on average with advancing maternal age, the high intra-age and intercenter variation in oocyte chromosome abnormalities emphasize the difficulty in estimating how many euploid oocytes a specific woman will have. This may have repercussions for fertility preservation where a defined number of eggs are currently frozen just based on maternal age.

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