Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study  

Oleh:

Scott, Richard T. ; Ferry, Kathleen M. ; Su, Jing ; Tao, Xin

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 97 no. 04 (Apr. 2012), page 870-875.
Topik: Comprehensive Chromosome Screening; SNP Microarray; Aneuploidy; Nonselection

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To determine both the negative and positive predictive values of comprehensive chromosome screening (CCS) results for clinical outcome. Design Data obtained from two prospective, double-blinded, nonselection studies. Setting Academic center for reproductive medicine. Patient(s) One hundred forty-six couples with a mean maternal age of 34.0 ± 4.4 years and a mean paternal age of 37.3 ± 5.8 years. Intervention(s) Embryo biopsy for DNA fingerprinting and aneuploidy assessment. Main Outcome Measure(s) Failure rate of embryos predicted aneuploid by CCS (negative predictive value) and success rate of embryos predicted euploid by CCS (positive predictive value). Result(s) A total of 255 IVF-derived human embryos were cultured and selected for transfer without influence from CCS analysis. Embryos were biopsied before transfer, including 113 blastomeres at the cleavage stage and 142 trophectoderm biopsies at the blastocyst stage. Comprehensive chromosome screening was highly predictive of clinical outcome, with 96% of aneuploid predicted embryos failing to sustain implantation and 41% sustained implantation from embryos predicted to be euploid

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali